WASHINGTON, D.C. – Today, the U.S. Environmental Protection Agency (EPA) finalized a rule that prevents companies from starting or resuming the manufacture or processing of 329 per- and poly-fluoroalkyl substances (PFAS) that have not been made or used for many years without a complete EPA review and risk determination. In the past, these chemicals, known as "inactive PFAS," may have been used without review in many industries, including as binding agents, surfactants, in the production of sealants and gaskets, and may also have been released into the environment.