In 2011, Mantegna starred in the found footage feature Apartment 143 and in the independent romantic comedy, Getting That Girl. In addition to film roles, she currently plays recurring characters on The Middle and Under the Dome.
In 2008, Mantegna made a guest appearance in the Season 3 episode, for television show Criminal Minds, in which her father stars, wherein she portrayed an abducted teen named Lindsey Vaughn, who witnesses her best friend’s death. She also appeared on The Secret Life of the American Teenager in a recurring role as Patty Mary.
In 1990, the couple had a second daughter, Gina, now 29, just as Joe began booking more TV and film roles, such as The Godfather III. She and her sister were close from the beginning. “She’s wise beyond her years and really understands Mia,” he told People.
Arlene managed the family and supported Joe’s acting career. Then in 2003, Joe supported Arlene’s dream of opening her own restaurant. They created Taste Chicago in Burbank, California, which served Chicago comfort foods such as Italian beef sandwiches, deep dish pizza, and Vienna Beef hotdogs in a poppy seed bun before closing in March 2019.
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In the same year, she had a recurring role in the TV show The Secret Life of the American Teenager, in which she played Patty Mary. In 2010, Mantegna simultaneously starred in the indie film And Soon the Darkness, in which she played Camila; and appeared in the television series Gigantic, in which she played Vanessa King. In the same year, she was announced as the 2011 Miss Golden Globe for the 68th Annual Golden Globe Award Ceremony. She is currently playing recurring roles in the TV shows The Middle and Under the Dome.
“Yes and no,” he says, noting that more attention is being paid because the number of cases has risen dramatically. (The prevalence of autism is about one to two per 1,000 people worldwide; however, the Centers for Disease Control and Prevention (CDC) reports approximately nine per 1,000 children in the United States are diagnosed with it.) Mantegna admires organizations such as Autism Speaks, which merged with Cure Autism Now in 2007.
While he hopes for earlier diagnosis or maybe a situation where they “twist a chromosome” to stop autism from occurring altogether, his focus these days is on the children who are young adults and older, like his daughter, who can never be totally independent. “These children only stay children for just so many years. In fact only about an eighth of their life. What do you do with these people for the other seven-eighths of their life? It doesn’t go away. When they cured polio, that’s fine. But how does it affect the guy who’s walking around with braces on his legs?”
The two actors started their careers together in “Hair” and were godfathers to each other’s children.
When a reporter for People magazine interviewed Joe Mantegna in the 1990s and asked if he had a daughter with autism, the actor made an important decision.